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RETATRUTIDE

$25.99 USD

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Retatrutide is an investigational triple receptor agonist peptide that simultaneously targets and activates the glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). This molecule is designed to explore potential mechanisms in regulating blood glucose, body weight, and energy metabolism through synergistic multi-pathway actions. This high-purity lyophilized peptide is intended for metabolic disease mechanism research and the development of novel multi-target therapies.

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Quantity	Discount	Price
1	0%	$25.99
2 - 5	5%	$24.69
6 - 10	10%	$23.39
11 - 15	15%	$22.09

Product details

Triple Agonist Activity: Single molecule acts on GLP-1R, GIPR, and GCGR simultaneously, suitable for multi-pathway metabolic regulation studies.

High Purity & Structural Accuracy: Solid-phase synthesized and purified via HPLC (≥98%), with sequence and modifications verified by mass spectrometry.

Long-Acting Design: Incorporates fatty acid chain modification for serum albumin binding, extending in vivo half-life, suitable for chronic animal models.

Mechanistic Research Tool: Provides a platform for studying multi-target synergy/antagonism, applicable to energy metabolism, appetite regulation, and insulin sensitivity mechanisms.

Mechanism of action

Retatrutide functions by activating three classes of G protein-coupled receptors closely involved in metabolism:

GLP-1R Activation: Promotes glucose-dependent insulin secretion, inhibits glucagon release, delays gastric emptying, and enhances satiety.
GIPR Activation: Enhances insulin secretion, promotes energy storage in adipose tissue, and may modulate bone metabolism.
GCGR Activation: Moderate activation increases energy expenditure, promotes hepatic gluconeogenesis and fatty acid oxidation, working synergistically with GLP-1R and GIPR to regulate energy balance.

Usage Guidelines (Research UseOnly):

Reconstitute using sterile saline or a specified buffer.

Store lyophilized powder sealed and protected from light at -20°C or below. After reconstitution, aliquot and freeze to avoid repeated freeze-thaw cycles to maintain peptide stability.

Suitable for in vitro wound healing assays, cell migration/proliferation analyses, or subcutaneous/intramuscular injection studies in animal models.

Specific dosage, frequency, and administration routes should be optimized based on published literature and preliminary experimental results, while strictly adhering to animal research ethical guidelines.

Packaging Instructions

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.

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