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SEMAX

$25.99 USD

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SEMAX is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from an active fragment of adrenocorticotropic hormone (ACTH). It is a synthetic peptide with neuroprotective, neuromodulatory, and nootropic potential, originally developed by the Russian Academy of Sciences as a research tool for nervous system disorders. SEMAX does not possess direct hormonal activity but exerts its effects through modulation of endogenous neurotransmitter systems and signaling pathways.

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Quantity	Discount	Price
1	0%	$25.99
2 - 5	5%	$24.69
6 - 10	10%	$23.39
11 - 15	15%	$22.09

Product details

Chemical Property: Synthetic heptapeptide with sequence: Met-Glu-His-Phe-Pro-Gly-Pro

Purity Grade: ≥98% (by HPLC analysis), meeting research-grade standards

Appearance: White to off-white lyophilized powder

Solubility: Freely soluble in water or saline; recommended for reconstitution with sterile water for injection or buffer solution

Storage Stability: Lyophilized form is stable for long-term storage at ≤ -20°C; after reconstitution, aliquoting and storage at -20°C or -80°C is recommended

Quality Verification: Molecular weight confirmed by mass spectrometry (MS), amino acid sequence validated

High-purity laboratory-grade material ensures reliable and accurate experimental data, specifically designed for tissue repair and cellular function research to support consistent results.

Stable and Easy-to-Use Formulation

Highly stable formulation, easy to handle and reconstitute under standard laboratory conditions.

Mechanism of action

SEMAX acts through multiple neuromodulatory and neuroprotective pathways:

Brain-Derived Neurotrophic Factor (BDNF) Modulation

Experimental studies indicate SEMAX upregulates BDNF expression, promoting neuronal survival, differentiation, and synaptic plasticity.

Endogenous Opioid System Regulation

May influence pain modulation and stress responses via enkephalin and endorphin pathways.

Antioxidant and Anti-Apoptotic Effects

Reduces oxidative stress by enhancing antioxidant enzyme activity (e.g., superoxide dismutase) and inhibiting apoptotic pathways.

Cerebral Blood Flow and Metabolism Modulation

Animal studies show improved cerebral blood flow and glucose metabolism, particularly under ischemic or hypoxic conditions.

Neurotransmitter Modulation

Affects dopamine, serotonin, and norepinephrine systems, potentially involved in cognitive and emotional regulation.

Usage Guidelines (Research UseOnly):

Reconstitution is recommended using sterile physiological saline or a designated buffer solution.

The lyophilized powder should be stored sealed and protected from light at -20°C or below. After reconstitution, it is advisable to aliquot and store at -80°C, avoiding repeated freeze-thaw cycles to maintain peptide stability.

Specific administration dosage, frequency, and routes should be optimized based on published literature and preliminary experimental results, while strictly adhering to animal experimental ethics guidelines.

Packaging Instructions

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.

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