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KISSPEPTIN-10

$45.99 USD

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Kisspeptin-10 is the core bioactive decapeptide fragment of the kisspeptin family (amino acid sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2). As a key signaling molecule in neuroendocrine regulation, it specifically activates the G protein-coupled receptor GPR54 (Kiss1R) in the hypothalamus, thereby controlling the secretion of gonadotropin-releasing hormone (GnRH) and playing a central role in the reproductive axis, puberty initiation, and sex hormone balance. This high-purity synthetic lyophilized peptide is designed for research in neuroendocrinology, reproductive physiology, and metabolic regulation.

size 5mg 10mg

Save up to 15% when you buy more!

Quantity	Discount	Price
1	0%	$45.99
2 - 5	5%	$43.69
6 - 10	10%	$41.39
11 - 15	15%	$39.09

Product details

High Purity & Precise Structure: Solid-phase synthesized, purified by HPLC (≥98%), with sequence verified via mass spectrometry (MS). C-terminal amidation ensures full bioactivity.

Strong Receptor Specificity: Specifically activates the GPR54 receptor, making it a classic tool peptide for studying the hypothalamic-pituitary-gonadal (HPG) axis.

Research-Grade Stability: Lyophilized form ensures long-term storage stability; reconstituted solution maintains activity under appropriate conditions, suitable for in vitro and animal models.

Well-Defined Function: Its physiological effect of stimulating GnRH/LH release has been extensively validated in various animal models (mice, rats, primates).

Mechanism of action

Receptor Binding: Kisspeptin-10 specifically binds to and activates the GPR54 receptor on hypothalamic GnRH neurons.
Signal Transduction: Activation of Gq/11 proteins triggers phospholipase C (PLC), generating IP3 and DAG, leading to increased intracellular calcium and PKC activation.
GnRH Release: This signaling cascade ultimately induces pulsatile GnRH release from GnRH neurons.
Downstream Effects: GnRH acts on the anterior pituitary to stimulate synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby regulating gonadal hormone synthesis, gametogenesis, and reproductive function.

Usage Guidelines (Research UseOnly):

Reconstitute using sterile saline or a specified buffer.

Store lyophilized powder sealed and protected from light at -20°C or below. After reconstitution, aliquot and freeze to avoid repeated freeze-thaw cycles to maintain peptide stability.

Suitable for in vitro wound healing assays, cell migration/proliferation analyses, or subcutaneous/intramuscular injection studies in animal models.

Specific dosage, frequency, and administration routes should be optimized based on published literature and preliminary experimental results, while strictly adhering to animal research ethical guidelines.

Packaging Instructions

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.

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