CHK-Cu

Biomimetic Metallopeptide Structure

Simulates the natural form of copper peptides in biological systems, offering high biocompatibility and stability for cellular and tissue-level mechanistic research.

Multifaceted Research Value

Suitable for exploring molecular pathways related to skin barrier repair, collagen synthesis regulation, oxidative stress protection, angiogenesis promotion, and microcirculation modulation.

High Purity and Stability
Prepared via coordination purification technology to ensure stable binding between copper ions and the cyclic peptide, with purity ≥97% (HPLC). Lyophilized form enables long-term storage and convenient handling.

High Experimental Compatibility

Compatible with cell cultures, 3D skin models, ex vivo tissue assays, and specific animal models. Supports various research approaches, including topical administration and culture medium supplementation.

Current research suggests the potential mechanisms of CHK‑Cu may involve the following synergistic pathways:

Angiogenesis Regulation: Copper ions are essential cofactors for key angiogenic enzymes (e.g., lysyl oxidase). The peptide component may facilitate targeted delivery of copper to endothelial cells, promoting microvessel formation.

Antioxidant & Anti‑Inflammatory Effects: The complex may mimic superoxide dismutase activity to scavenge reactive oxygen species and modulate inflammation‑related signaling pathways synergistically.

Extracellular Matrix Remodeling: By supplying bioavailable copper, it supports the cross‑linking and maturation of collagen and elastin, thereby aiding skin and connective tissue repair.

Cellular Signaling Activation: The peptide component may mimic growth factor functions, interacting with cell‑surface receptors and synergizing with copper ions to activate downstream pro‑survival and proliferative pathways.

Reconstitution: Slowly reconstitute with sterile saline or PBS buffer, avoiding vigorous shaking to prevent loss of activity.

Experimental Design: Determine concentration ranges (common range: 0.1–10 µM) with reference to current literature and validate through pilot experiments.

Storage Conditions: Store lyophilized powder protected from light at -20°C or below. After reconstitution, aliquot and freeze; avoid repeated freeze-thaw cycles (recommended ≤3 cycles).

Important Notes: This product is for research purposes only. Not for human or clinical use. Always wear appropriate personal protective equipment and adhere to laboratory safety protocols during handling.

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.