CAGRILINTIDE

High-Purity Synthesis: Solid-phase synthesis combined with HPLC purification achieving ≥98% purity (HPLC-verified), with molecular weight and sequence confirmed by mass spectrometryLong-Acting Molecular Design: C20 fatty diacid modification enables reversible albumin binding, significantly extending in vivo half-life to support once-weekly dosing researchDual Receptor Targeting: Functions as a non-selective dual agonist of amylin receptors (AMYRs) and calcitonin receptors (CTR)Research-Grade Stability: Lyophilized powder ensures high stability; reconstituted solution maintains activity for cell and animal studies

Cagrilintide mimics the biological functions of native amylin, activating multiple central and peripheral signaling pathways:Central Appetite Regulation: Activates AMYR receptors in the hypothalamus and hindbrain regions (e.g., nucleus tractus solitarius, area postrema), inhibiting hunger signaling and promoting satietyDual Receptor Agonism: Simultaneously targets AMYRs and CTR. Evidence suggests that co-activation of both receptors may produce superior metabolic effects compared to selective AMYR agonists aloneGastric Emptying Delay: Reduces food intake and stabilizes postprandial glucose excursions by slowing gastric emptyingRenal Metabolic Modulation: In diabetic models, cagrilintide increases intracellular cAMP levels in cortical tubules and modulates ion transporter phosphorylation statusStructural biology studies reveal that while cagrilintide shares a highly similar receptor binding mode with native amylin, it induces distinctive conformational dynamics in receptor complexes—a feature that may underlie its superior clinical efficacy compared to earlier analogues.

Storage:Lyophilized Powder: Store at ≤ -20°C, protected from light, for optimal long-term stability.|Reconstituted Solution: Aliquot immediately and store at -80°C. Avoid repeated freeze-thaw cycles to preserve activity.Critical Notes:Research Use Only: Not for human or clinical use.Experimental Design: Account for its onset, plateau, and washout periods due to its prolonged action.Compliance: All research must adhere to institutional animal ethics and biosafety guidelines.

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.