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5-AMINO-1MQ

$55.90 USD

~~$65.60 USD~~ $55.90 USD

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5‑amino‑1MQ is a potent and selective small‑molecule inhibitor of nicotinamide N‑methyltransferase (NNMT). NNMT catalyzes the methylation of nicotinamide (NAM) to 1‑methylnicotinamide (1‑MNA), consuming the methyl donor SAM and thereby affecting cellular methylation homeostasis and energy metabolism. This high‑purity crystalline powder serves as an ideal chemical probe for studying the role of NNMT in metabolic reprogramming, aging, and age‑related diseases.

Size 5mg 10mg 50mg

Save up to 15% when you buy more!

Quantity	Discount	Price
1	0%	$50.90
2 - 5	3%	$49.37
6 - 10	7%	$47.34
11 - 15	10%	$45.81

Product details

Amino Acid Sequence

Tyr–Leu–Arg–Ile–Val–Gln–Cys–Arg–Ser–Val–Glu–Gly–Ser–Cys–Gly–Phe

Molecular Formula

C₇₈H₁₂₃N₂₃O₂₃S₂

Molecular Weight

1815.1 g/mol

PubChem CID

71300630

CAS Number

221231-10-3

Vial Size

3ml

Lyophilized powder, white/off-white color

Mechanism of action

Inhibition of NNMT Activity: Competitively blocks NAM methylation, reducing 1‑MNA production.

Restoration of Methylation Homeostasis: Decreases SAM consumption, increases SAM/SAH ratio, and promotes global protein/DNA methylation.

Elevation of NAD+ Levels: Reduces diversion of NAM into methylation, boosting NAD+ biosynthesis precursors and activating NAD+‑dependent deacetylases (e.g., Sirtuins).

Improvement of Metabolic Phenotype: In metabolic disorder models, reverses high‑fat‑induced insulin resistance, reduces fat accumulation, and enhances mitochondrial function.

Usage Guidelines (Research UseOnly):

Storage:Lyophilized Powder: Store at ≤ -20°C, protected from light, for optimal long-term stability.|Reconstituted Solution: Aliquot immediately and store at -80°C. Avoid repeated freeze-thaw cycles to preserve activity.Critical Notes:Research Use Only: Not for human or clinical use.Experimental Design: Account for its onset, plateau, and washout periods due to its prolonged action.Compliance: All research must adhere to institutional animal ethics and biosafety guidelines.

Packaging Instructions

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.

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