TB-500

TB-500 is a synthetic 43-amino acid peptide whose sequence corresponds to the core active region of natural human Thymosin Beta-4. Thymosin Beta-4 is an intracellular actin-regulating protein widely expressed in cells. Preclinical studies have shown that TB-500 exhibits strong abilities to promote cell migration, angiogenesis, and anti-inflammatory effects, making it a compound of significant interest in tissue repair and regenerative medicine research.

The mechanism of TB-500 primarily involves the following aspects:Promotion of Cell Migration: By binding to actin monomers, it regulates cytoskeletal reorganization, accelerating the migration of various cells (e.g., endothelial cells, fibroblasts) to injury sites.Stimulation of Angiogenesis: Upregulates pro-angiogenic factors such as VEGF, promoting new blood vessel formation and improving blood supply to injured tissues.Anti-Inflammatory Effects: Reduces the release of pro-inflammatory cytokines and increases anti-inflammatory mediators, helping to control excessive inflammatory responses post-injury.Enhancement of Cell Survival: Activates cell survival signaling pathways (e.g., the Akt pathway), reducing apoptosis.

It is recommended to reconstitute using sterile saline or the specified buffer.

Use individually or in combination, as specified in the experimental design.

Store lyophilized powder sealed and protected from light at -20°C or below. After reconstitution, aliquot and freeze （-80°C）to avoid repeated freeze-thaw cycles to maintain peptide stability.

Specific dosage, frequency, and administration routes should be optimized based on published literature and preliminary experimental results, while strictly adhering to animal research ethical guidelines.

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.