TIRZEPATIDE

• Dual Receptor Agonism: Efficiently activates both GIP and GLP-1 receptors, suitable for comparative studies between single- and multi-target agonists
• Extended Half-Life Design: Fatty acid side chain modification enables reversible binding to plasma proteins, extending half-life to approximately 5–7 days, ideal for long-term metabolic studies
• High-Purity Synthesis: Solid-phase synthesized and purified via HPLC (≥98%), with sequence and modification verified by mass spectrometry
• Metabolic Research Ready: Provides a stable and reliable tool for in vitro and in vivo metabolic research, suitable for pharmacodynamic and mechanistic studies

1. Glucose Regulation:Activates GLP-1 receptors to enhance glucose-dependent insulin secretion and suppress glucagon releaseConcurrently activates GIP receptors to further stimulate insulin secretion and improve insulin sensitivity
2. Body Weight & Appetite Regulation:Dual agonism synergistically delays gastric emptying, enhances satiety signaling, and suppresses appetite centersModulates lipid metabolism and energy expenditure to promote weight loss
3. Cardiometabolic Protection:Improves lipid profiles, reduces inflammatory responses, and exhibits potential cardiovascular benefitsMay ameliorate metabolic complications such as non-alcoholic fatty liver disease through multi-target synergy

• Reconstitution: Reconstitute with a sterile pH-buffered solution (e.g., 0.1M NaOH or phosphate buffer adjusted to pH 8.0–9.0) to maintain stability and solubility
• In Vitro Experiments:Typical concentration range for receptor activation assays: 0.1 nM – 100 nMPre-experimental optimization recommended for cAMP or insulin secretion assays
• Animal Studies:Dosage: Common doses in mouse/rat studies range from 0.1–1 mg/kg, administered via subcutaneous injection once or twice weeklyModel Applications: Suitable for obesity, type 2 diabetes, non-alcoholic fatty liver disease, and other metabolic disorder models
• Storage:Lyophilized Powder: Store at ≤ -20°C protected from light; long-term storage at -80°C is recommendedReconstituted Solution: Aliquot immediately and store at -80°C; avoid repeated freeze-thaw cycles (single-use aliquots suggested)
• Critical Notes:Research Use Only: This product is for research purposes only and is not intended for human or clinical useMechanistic Validation: Effects should be validated using receptor activation assays, insulin/glucagon measurements, glucose tolerance tests, etc.Ethical Compliance: Animal studies must be approved by institutional animal ethics committees and follow animal welfare guidelines

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.