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IGF-1 LR3

$79.99 USD

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IGF-1 LR3 (Long Arg³ IGF-1 analog) is a synthetic derivative of insulin-like growth factor-1, engineered with amino acid substitutions and an N-terminal extension to significantly enhance its stability and bioactivity. In research, it exhibits stronger receptor affinity and a longer half-life compared to natural IGF-1, and is widely used in studies involving cell proliferation, differentiation, metabolism, and related signaling pathways.

size 1mg

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Quantity	Discount	Price
1	0%	$79.99
2 - 5	5%	$75.99
6 - 10	10%	$71.99
11 - 15	15%	$67.99

Product details

High Bioactivity: Structurally optimized for enhanced IGF-1 receptor activation, suitable for low-concentration experimental conditions.

Improved Stability: Modified to resist degradation, maintaining longer-lasting activity in vitro.

Broad Research Applicability: Applicable to studies in muscle growth, bone metabolism, neuroprotection, wound healing, and tumor cell mechanisms.

Rigorous Quality Control and Stability

High-purity laboratory-grade material ensures reliable and accurate experimental data, specifically designed for tissue repair and cellular function research to support consistent results.

Stable and Easy-to-Use Formulation

Highly stable formulation, easy to handle and reconstitute under standard laboratory conditions.

Mechanism of action

IGF-1 LR3 binds to and activates the cell-surface IGF-1 receptor (IGF-1R), triggering its intrinsic tyrosine kinase activity and initiating downstream signaling cascades, primarily:

PI3K/Akt Pathway: Promotes glucose uptake, protein synthesis, cell survival, and proliferation

MAPK/Erk Pathway: Regulates cell cycle progression and differentiation

Downstream Effects: Mediates anabolic responses, inhibits protein degradation, and promotes mitosis and differentiation

Its modified structure allows it to reach target tissues more efficiently in its free form, enhancing receptor activation efficiency and duration.

Usage Guidelines (Research UseOnly):

Reconstitute using sterile saline or a specified buffer.

Store lyophilized powder sealed and protected from light at -20°C or below. After reconstitution, aliquot and freeze to avoid repeated freeze-thaw cycles to maintain peptide stability.

Suitable for in vitro wound healing assays, cell migration/proliferation analyses, or subcutaneous/intramuscular injection studies in animal models.

Specific dosage, frequency, and administration routes should be optimized based on published literature and preliminary experimental results, while strictly adhering to animal research ethical guidelines.

Packaging Instructions

Packaging Note: This product is supplied in a sealed, sterile glass vial without any pre‑printed labels. This design supports institutional compliance protocols and allows researchers to apply custom labels that align with specific experimental protocols, ethical approvals, and local regulations. A separate document containing complete product details (name, batch number, purity, content, COA reference, etc.) is included for label customization and record‑keeping.

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